Life Science Workflows
DNA-FISH & Genomic Imaging
Fluorescence in situ hybridization with multi-channel detection
Perform DNA-FISH experiments on the openUC2 platform. Multi-channel fluorescence imaging with automated tile scanning enables detection of specific genomic loci, chromosomal aberrations, and gene copy number variations. The open software stack integrates with existing FISH analysis tools.
Technical specifications
| Excitation | Multi-channel LED (405/470/530/590/630 nm) |
|---|---|
| Detection | Up to 5 fluorescence channels |
| Objectives | 40x-100x oil immersion recommended |
| Z-stacks | 0.2-1 um step size for 3D FISH analysis |
| Tile scanning | Automated multi-position acquisition |
| Analysis | Compatible with FISH analysis tools (FISHquant, BigFISH) |
Key capabilities
Multi-channel detection
Image up to 5 fluorescence channels for multi-probe FISH experiments.
Z-stack acquisition
Capture 3D volumes for accurate spot detection and localization.
Automated scanning
Scan multiple fields of view and hundreds of cells automatically.
Open analysis pipeline
Export data for analysis in FISHquant, BigFISH, or custom Python scripts.
On the roadmap
Integrated spot detection in ImSwitch
Sequential FISH (seqFISH) protocol support
Automated cell segmentation and spot assignment
Interested in dna-fish & genomic imaging?
Tell us about your imaging needs and we'll help you find the right configuration.